Micky van de Ven Brace Halts The Toffees' Unbeaten Streak at Brand New Stadium
The Dutch defender emerged as the initial defender to net two goals in a English top-flight match for Tottenham since Jan Vertonghen in March 2013.
Match summary
Micky Van de Ven heads into the net two times in first half
Everton's Jake O'Brien has goal ruled after VAR review
Senegalese midfielder scores final goal in dying moments
This loss is the Merseyside club's initial at Hill Dickinson Stadium
The Tottenham defender found the net on two occasions as Spurs extended their unbeaten run in away games in the Premier League and handed Everton their first defeat at their new home.
Everton were undefeated in their last five matches at their recently opened stadium at Bramley-Moore Dock, having left their historic home behind after more than a century at the conclusion of the previous campaign.
But Spurs captain Van de Ven pounced on two occasions from set-pieces in the first half to put their impressive record at risk, and they were unable to turn it around before the midfielder - assisted by former Toffees attacker the Brazilian - headed home a third to seal the victory.
The Everton defender thought he had levelled the tally a short while after the defender's opener, directing a powerful header past the Spurs keeper from an Everton corner.
Beto, meanwhile, missed a number of chances, while Vicario made a series of excellent stops to guarantee Tottenham went five away games without defeat in the English top flight.
But the VAR intervened, instructing Craig Pawson to review the score on the pitchside monitor and the referee decided that Jack Grealish and Iliman Ndiaye were in offside positions and had interfered with the Spurs keeper.
This victory elevates Thomas Frank's side into third place in the Premier League, five points off north London rivals and leaders Arsenal.
Everton remain 14th and sit six points clear of the drop zone.
Tottenham analysis: The defender excels in role at each end of the field
Following a drab weekday performance in the European competition against Monaco, where they managed a only two shots on goal, the manager opted for Randal Kolo Muani up front instead of former Toffees player the Brazilian.
The summer signing was unable to influence the game before being substituted for the substitute after 60 minutes on the field, but it turns out he wasn't needed in the final outcome.
Centre-back Van de Ven converted into an offensive threat to be feared.
Spurs' first goal came from a well-worked set-piece play, with the midfielder heading the ball toward the face of goal for an free the defender to head home.
And Ven de Ven - filling in as captain in Cristian Romero's absence - notched his second in added time as he outjumped Jordan Pickford to nod in.
Van de Ven was just as impressive in defence, combining well with Kevin Danso as the duo handled excellently with the 34 crosses thrown their way by Everton.
Everton analysis: Everton lacking finishing touch
The club's new home had been a happy hunting ground, but it appears the novelty may have faded slightly and supporters flocked to the exits after Sarr's final goal for Tottenham.
The break in the team's unbeaten home run won't be a major concern for the manager, but their attacking woes are.
Beto and the other striker - the Everton's pair of established centre-forwards - had scored only a single goal between them before the weekend's match.
And they were unable to add to that poor record on a damp and dreary night on in Liverpool.
Beto's form was epitomized when he chose to overhead kick a golden opportunity from close range, despite having space and opportunity to reposition for a more conventional attempt that would have tested Vicario.
The substitute, too, failed to make an impact after coming on for Beto in the 65th minute.
It wasn't for a lack of opportunity. The majority of Everton's attacks came through Grealish and the forward, who relentlessly delivered dangerous crosses into the Tottenham box.
Upcoming fixtures for both teams?
Everton: The team head to the Stadium of Light in the top flight on Monday, 3 November at 20:00 GMT.
Tottenham: Spurs travel to St James' Park on Wednesday, 29 October for their fourth-round Carabao Cup match against Newcastle.